Biliary Tract Excretion of Cefazolin, Cephalothin, and Cephaloridine in the Presence of Biliary Tract Disease

Biliary tract excretion of cefazolin, cephalothin, and cephaloridine in the presence of biliary tract disease.

The biliary tract excretion of three cephalosporins, cefazolin, cephaloridine, and cephalothin, was compared in patients with biliary tract disease. In the absence of obstruction, mean antibiotic levels in bile from gall bladder and common duct in patients undergoing cholecystectomy were highest for cefazolin (17 and 31 mug/ml, respectively) than either cephaloridine (7 and 9 mug/ml) or cephalo...

Pharmacology of cephalothin in the biliary tract of humans.

Serum and biliary tract levels of cephalothin were determined in a large series of patients. Serum cephalothin levels in the therapeutic range were present at 1 h after a single dose of the antibiotic in only 4 of 39 (10.3%) subjects. Therapeutic bile cephalothin levels were achieved in only 2.4% of all subjects, and this occurred between 40 and 70 min after the administration of the antibiotic.

Bacteria and disease of the biliary tract.

Three Living Fasciola Hepatica in the Biliary Tract of a Woman

Fasciola hepatica (F. hepatica) as a foodborne trematode can occasionally cause hepatobiliary diseases. We report a 67-year-old woman who was referred to our center because of the diagnosis of cholangitis. She was a resident of mountainous area with the history of unsafe water and contaminated vegetables. Endoscopic retrograde cholangiopancreatography (ERCP) was performed as a diagnostic and th...

Biliary Tract Cancers: Extrahepatic Management Biliary Tract Cancers

Interventional radiologists fi rst became involved in the management of malignant obstruction of the biliary tree in the late 1960s, when Kaude et al. introduced nonsurgical biliary drainage. Since then, improved diagnostic imaging techniques, significant developments in interventional radiology, and the results of clinical trials have revolutionized and clearly defi ned the role of percutaneou...